Are you a neuroscientist looking to contribute to groundbreaking research in experimental or computational neuroscience? George Mason University is offering two exciting postdoctoral positions, providing a unique opportunity to explore the neural mechanisms behind age-related memory decline. Here’s a detailed overview of these roles, the research project, and why this opportunity at the Center for Neural Informatics, Structures, and Plasticity (CN3) could be your next career milestone.
Overview of Postdoctoral Fellow Positions
George Mason University is seeking candidates for two full-time postdoctoral positions:
- Computational Neuroscientist: Focused on large-scale spiking neural network modeling.
- Experimental Neuroscientist: Centered on single-unit recordings and fiber photometry in freely behaving mice.
Both positions involve collaborative research under the mentorship of Professors Giorgio Ascoli and Holger Dannenberg. These roles are fully funded and come with competitive benefits for Virginia state employees.
About the Research Project
Objective
The research investigates how aging impacts cholinergic modulation in the hippocampal CA3 area, a region critical for spatial memory and cognitive function. The work aims to reveal mechanisms underlying age-related memory decline and develop potential interventions for Alzheimer’s disease.
Focus Areas
- Cholinergic Neuromodulation: Exploring how changes in acetylcholine release affect memory encoding and retrieval.
- Integration of Computational Models and Experimental Data: Using cutting-edge neural data to inform biologically realistic spiking neural network models.
This National Institutes of Aging (NIA)-funded project leverages advanced experimental and computational approaches to unravel these complex processes.
Position 1: Computational Neuroscientist
Key Responsibilities
- Model Development: Expand a data-driven spiking neural network model of hippocampal CA3.
- Simulation: Implement simulations using the CarlSim environment on Mason’s GPU supercomputer.
- Data Integration: Incorporate behavioral dynamics and cholinergic modulation data.
- Analysis: Design and test hypotheses to understand the cognitive impact of aging.
Preferred Skills
- Expertise in C++ and Python programming.
- Experience with GPU high-performance computing and neural network modeling.
This role emphasizes the fusion of computational precision with experimental insights to elucidate memory processes.
Position 2: Experimental Neuroscientist
Key Responsibilities
- Neural Recordings: Perform single-unit recordings in hippocampal area CA3 using tetrodes and neuropixels.
- Cholinergic Modulation Studies: Measure acetylcholine release using fiber photometry in behaving mice.
- Behavioral Analysis: Investigate spatial memory encoding and retrieval tasks.
Preferred Skills
- Proficiency in electrophysiology and survival surgeries in rodents.
- Knowledge of Matlab or Python for data analysis.
This position focuses on acquiring high-quality experimental data to inform computational models and validate hypotheses.
Collaborative Environment and Mentorship
Research Labs
The postdoctoral fellows will work within two renowned labs:
- Giorgio Ascoli’s Lab: Specializes in computational neuroanatomy and large-scale data-driven modeling.
- Holger Dannenberg’s Lab: Focuses on experimental studies of memory and neural plasticity.
Collaborative Support
- Regular interdisciplinary meetings to synchronize experimental and computational insights.
- Mentorship opportunities for guiding graduate and undergraduate researchers.
Workplace Benefits and Opportunities
State Employee Benefits
- Generous retirement plans.
- Comprehensive family health insurance.
- Paid leave.
Research Facilities
The Krasnow Institute at George Mason University provides:
- An AALAC-accredited vivarium for rodent studies.
- Advanced tools for behavioral experiments and neural recordings.
Proximity to Washington, D.C.
Located just 20 miles from Washington, D.C., the university offers unparalleled access to:
- Federal research agencies (e.g., NIH).
- Collaborative opportunities with high-tech industries.
Qualifications and Requirements
Mandatory Qualifications
- A completed doctoral degree (PhD, MD, or equivalent) in neuroscience, bioengineering, or a related STEM field.
- Strong programming, analytical, and quantitative reasoning skills.
- Proficiency in English and excellent communication abilities.
Desired Qualifications
- Computational Position: Expertise in spiking neural networks and computational tools.
- Experimental Position: Experience in in-vivo electrophysiology, optogenetics, or fiber photometry.
Commitment to Diversity
George Mason University values diversity and inclusivity. Candidates from underrepresented groups are strongly encouraged to apply.
How to Apply
Application Components
To apply, candidates must submit:
- Cover Letter: Highlighting relevant experience, research goals, and career aspirations.
- CV/Resume: Comprehensive academic and professional record.
- Coursework Transcripts: For undergraduate and graduate studies.
- Publications: Links to two sample publications or preprints.
- Recommendation Letters: One letter from a PhD advisor and one additional reference.
Submission
Email all materials to:
Applications are reviewed on a rolling basis.
Research Impact and Career Growth
Research Significance
This research offers critical insights into Alzheimer’s disease and cognitive decline, with implications for therapeutic strategies.
Career Advancement
- Opportunities to publish in high-impact journals.
- Presentation of findings at international conferences.
- Mentorship experience for aspiring scientists.
Why Join George Mason University?
Top-Ranked Institution
As Virginia’s largest and most diverse public research university, Mason boasts an R1 research designation and a dynamic academic environment.
State-of-the-Art Research
- CN3 fosters interdisciplinary neuroscience studies integrating psychology, neurobiology, and computational science.
- Cutting-edge facilities for both experimental and computational research.
FAQs
1. What is the primary focus of these postdoctoral positions?
The focus is on investigating the effects of aging on cholinergic modulation in the hippocampus and its impact on memory.
2. What is the required expertise for the computational position?
Candidates should have experience in spiking neural network modeling, GPU computing, and programming in C++ and Python.
3. What experimental techniques will be employed?
The experimentalist will use single-unit recordings, fiber photometry, and behavioral testing in rodents.
4. What are the benefits of these positions?
These are fully benefited positions with family health insurance, retirement plans, and paid leave.
5. What makes George Mason University unique for research?
Mason is an R1 research institution offering a multidisciplinary approach, state-of-the-art facilities, and proximity to federal research agencies and high-tech industries.